The service, presided over by the Bishop of Bukedi Diocese, Rt Rev Samuel Bogere Egessa, turned into an emotional homecoming as residents thronged the venue to welcome their newly elevated leader.
Although Oboth-Oboth arrived in Tororo District on Friday, he said he deliberately avoided a public procession because of security concerns arising from the Ebola outbreak and the large crowds expected to receive him.
Addressing the congregation, the Speaker became emotional as he recounted the reception he received upon returning home, saying many residents waited for him until late into the night.
"I stayed in Tororo until around 9pm to avoid a procession, but when I reached home, I found people waiting. We had prepared food but about half of them refused to eat. They were just dancing and crying with joy," he said.
He described the reception as deeply humbling, adding that he was still coming to terms with his appointment to one of the country's highest offices.
Reflecting on his upbringing, Oboth-Oboth said his journey from a humble family to becoming Speaker of Parliament was possible only through God's grace.
"I scored aggregate seven and was the second-best student in the district. My parents, being peasants, could not afford to take me to Majasi High School. To see someone like me become Speaker of Parliament can only be God's doing," he said.
The Speaker also alleged that some people were attempting to harm him through witchcraft and appealed to his constituents to continue praying for his safety.
"They want me dead. Those involved in such acts should stop. I believe I am God-made. Those who have tried have failed and will continue to fail," he said.
He also called on leaders in Tororo District and the wider Bukedi sub-region to intensify efforts to eliminate corruption, warning that national anti-corruption initiatives would be undermined if malpractice persisted at the local level.
"From Parliament, Tororo and Bukedi should not be associated with corruption in district offices or the sale of jobs. We must maintain a clean background as we fight corruption nationally," he said.
Oboth-Oboth said corruption continues to undermine service delivery in critical sectors, including healthcare, education and infrastructure.
In his sermon, Bishop Samuel Bogere Egessa warned that corruption had become deeply entrenched in both public institutions and religious spaces, describing it as one of the greatest obstacles to development in Bukedi.
"Corruption has entered our minds and is affecting service delivery. When health centres lack drugs, schools are understaffed and roads are impassable, these are clear signs of corruption," the bishop said.
He also called for accountability in the implementation of government programmes such as the Parish Development Model (PDM), cautioning against the extortion of beneficiaries.
Tororo County South Member of Parliament Frederick Angura welcomed Oboth-Oboth's elevation, saying it presents an opportunity for the region to lobby for improved infrastructure and public services.
"Having the Speaker from our area is a major milestone. It gives us leverage to advocate for better roads and improved services for our people," Angura said.
Oboth-Oboth also announced plans to hold a thanksgiving ceremony in his constituency and urged residents to remain patient as preparations continue.
He said President Museveni is expected to attend the event as the guest of honour, although the date is yet to be announced.