The accident occurred Friday afternoon at Muwayo village along Bugiri-Tororo highway.
James Mubi, the Busoga East region Police spokesperson, confirmed the incident.
The deceased was only identified as Dilausi the driver of the tipper a resident of busimi village Kibale subcounty namutumba district.
The injured were identified as Mulumba Dominic (32), Mukose Paul (50), and Wambi Micheal (54) all residents of Kibale subcounty in Namutumba district.
According to Mubi, the injured were rushed to Bugiri Hospital in critical condition.
The driver of the Mitsubishi pickup took off
He attributed the cause of the accident to over speeding adding that the wreckage of the vehicles were towed to bugiri police station.
He advised drivers to drive carefully in this festive season saying many people are travelling upcountry for Christmas holidays.
By press time the body was still at Bugiri Hospital for postmortem as investigation continue.