In a statement issued on Tuesday, UNICEF Representative to Uganda Dr Robin Nandy expressed deep sorrow over the tragedies and extended condolences to the bereaved families, classmates, schools and communities.
"No parent should send a child to school and never see them return home," Dr. Nandy said.
"Every child lost on Uganda's roads is one too many."
UNICEF said every child has the right to travel safely to and from school, describing road safety as a child rights issue closely linked to children's survival, education and the right to a safe environment.
The agency welcomed the government's decision to intensify enforcement of traffic regulations following the recent crashes and commended the Ministry of Education and Sports for suspending all school trips as it reviews and strengthens guidelines governing school travel.
Under the revised measures, schools have been directed to use only roadworthy, licensed vehicles operated by qualified and well-rested drivers. They are also required to conduct comprehensive risk assessments before journeys and ensure adequate teacher supervision throughout school trips.
Despite these interventions, UNICEF said more must be done to protect children on Uganda's roads.
The agency called for stricter enforcement of speed limits, particularly around schools, the construction of safer pedestrian crossings and walkways, and stronger emergency medical response systems for road crash victims.
UNICEF also highlighted the global scale of the problem, noting that road traffic injuries are the leading cause of death among children and adolescents aged between five and 19 years, with low- and middle-income countries bearing the greatest burden.
The organisation stressed that speed management remains one of the most effective ways to save lives, noting that a child struck by a vehicle travelling at 30 kilometres per hour has a significantly greater chance of survival than one hit at 50 kilometres per hour.
As Uganda mourns the recent loss of young lives, UNICEF urged government institutions, schools, transport operators, parents and communities to work together to strengthen road safety measures and ensure every child can travel to school safely and return home unharmed.