The latest victim of the coronavirus? A four-year-old female Malayan tiger at the Bronx Zoo in New York City.
Nadia, along with her sister Azul, two Amur tigers and three African lions had all developed a dry cough, said the Bronx zoo's chief veterinarian.
The big cats are believed to have been infected by a zookeeper - but all are expected to make a full recovery.
This case is being described as unusual because coronavirus transmissions from humans to animals have been rare and not well understood so far.
For most people, the virus causes symptoms like a cough or fever - but we still don't know much about what symptoms it could cause in animals, or in fact, very much at all about the different ways animals could be affected by it.
The cats started showing symptoms, including a dry cough, late last month after exposure to the employee, who has not been identified.
"This is the first time that any of us know of anywhere in the world that a person infected the animal and the animal got sick," Paul Calle, the chief veterinarian at the zoo, told Reuters news agency on Sunday.
He said he intends to share the findings with other zoos and institutions researching the transmission of Covid-19.
"We tested the cat [Nadia] out of an abundance of caution and will ensure any knowledge we gain about Covid-19 will contribute to the world's continuing understanding of this novel coronavirus," the zoo said in a statement.
Nadia, her sister Azul, as well as two Amur tigers and three African lions who showed symptoms, are all expected to make a full recovery, the zoo said.
The big cats did have some decrease in appetite but "are otherwise doing well under veterinary care and are bright, alert, and interactive with their keepers", it said.
The zoo said it is not known how the virus will develop in animals like tigers and lions since various species can react differently to new infections, but all the animals will be closely monitored.
None of the zoo's other big cats - four other tigers, snow leopards, cheetahs, a clouded leopard, an Amur leopard, a puma and a serval - are showing any signs of illness.
"Our cats were infected by a person caring for them who was asymptomatically infected with the virus or before that person developed symptoms," said the zoo.
All the tigers showing symptoms were housed in the zoo's Tiger Mountain area.
All four zoos run by the Wildlife Conservation Society in New York City, including the Bronx Zoo, have been closed to the public since 16 March. New measures will now be put in place to protect the animals and their caretakers at all the facilities.
What do we know about coronavirus in animals?
This case is being described as unusual because coronavirus transmissions from humans to animals have been rare and not well understood so far.
A handful of coronavirus cases have been reported in Hong Kong, including that of a dog that tested positive for a low level of the disease.
The coronavirus was first detected in the Chinese city of Wuhan late last year.
The coronavirus (called Sars-CoV-2, which causes the disease Covid-19) is thought to have originated in wildlife and been passed to humans via a live animal market in Wuhan.
The pandemic has been driven by human-to-human transmission, but the infection of Nadia raises new questions about human-to-animal transmission.
There is "no evidence that any person has been infected with Covid-19 in the US by animals, including by pet dogs or cats," the zoo statement noted.
That is also the view of the World Health Organization (WHO), which says there is no evidence that pet dogs or cats can pass on the coronavirus.
However, conservation experts have warned that the virus could pose a threat to some wildlife like the great apes - and have said measures are needed to reduce the risk of wild gorillas, chimps and orangutans.
